Labarai

A shekarar 1968, Kruger-Theimer ya nuna yadda za a iya amfani da samfuran pharmacokinetic don tsara ingantattun hanyoyin magani. Wannan tsarin Bolus, Elimination, Transfer (BET) ya ƙunshi:

allurar bolus da aka ƙididdige don cike babban sashin (jini),

jiko mai daidaito daidai da ƙimar kawarwa,

jiko wanda ke rama canjin zuwa kyallen da ke kewaye: [yawan raguwar saurin amsawa]

Aikin gargajiya ya haɗa da lissafin tsarin jiko na propofol ta hanyar hanyar Roberts. Ana bin kashi 1.5 mg/kg na lodi sannan a jiko 10 mg/kg/hour wanda aka rage zuwa 8 da 6 mg/kg/hour a tazara ta mintuna goma.

Yin niyya ga shafin sakamako

Babban tasirinmaganin sa barciMagungunan jijiyoyi sune tasirin kwantar da hankali da kuma hypnotic kuma wurin da maganin ke yin waɗannan tasirin, wanda ake kira wurin tasirin shine kwakwalwa. Abin takaici, ba zai yiwu a yi auna yawan kwakwalwa ba [wurin tasirin]. Ko da za mu iya auna yawan kwakwalwa kai tsaye, zai zama dole a san ainihin yawan yankuna ko ma yawan masu karɓa inda maganin ke yin tasirinsa.

Samun isasshen yawan propofol

Zane da ke ƙasa yana nuna yawan jiko da ake buƙata a raguwar saurin magani bayan shan maganin bolus domin a ci gaba da samun daidaiton yawan propofol a cikin jini. Hakanan yana nuna jinkiri tsakanin yawan jinin da wurin da aka yi amfani da shi.